FERM domain-containing protein 5 (FRMD5)

FERM domain-containing protein 5 (FRMD5) is a cytoskeletal regulatory protein belonging to the FERM domain family, which links the plasma membrane to the cytoskeleton, localizes at adherens junctions, and stabilizes cell-cell contacts[3][4]. FRMD5 is implicated in the context-dependent regulation of cell adhesion, migration, and transcription, functioning as part of signaling pathways that regulate actin cytoskeleton dynamics via interactions with integrin β5 and ROCK1 kinase[1][3][4]. In cancers such as hepatocellular carcinoma, lung cancer, and papillary thyroid carcinoma, FRMD5 expression and activity can influence tumor cell migration, invasion, adhesion, and multidrug resistance, acting as either a tumor suppressor or promoter depending on tissue and oncogenic context[1][2][4]. Variants in FRMD5 are also associated with neurological diseases including developmental delay, ataxia, and seizures[4]. The protein’s diverse cellular roles identify it as both a biomarker and potential therapeutic target in oncology and neurodevelopmental disease[1][2][3][4].

Other names

FRMD5MGC14161NEDEMAFERM domain containing 5

No mechanism of action for drugs, as no drugs directly targeting FRMD5 are described