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Target intelligence / Profile preview
Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDXACB1)
- Target
- FDXACB1
- Molecular classification
- Other (contains a ferredoxin-fold anticodon-binding domain; not a classic receptor, enzyme, transporter, or transcription factor)
01
Overview
Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDXACB1) is a human protein encoded by the FDXACB1 gene on chromosome 11. It contains a ferredoxin-like domain associated with anticodon binding, found in subsets of phenylalanyl tRNA synthetases, enzymes important for charging tRNAs during protein synthesis. The specific biological role of FDXACB1 in humans remains unclear, but it is suggested to participate in some aspect of RNA modification, such as rRNA methylation, based on sequence homology and predictions. There are currently no drugs or major disease associations for this protein, and it is not used as a therapeutic or diagnostic target.
- Other names
- hCG_2033039LOC91893FDX-ACDB domain-containing protein 1hypothetical protein BC006136
02
Mechanism of action
None reported for drugs (no drugs known to target this protein directly)
03
Biological functions
RNA binding (anticodon recognition domain)Possibly involved in tRNA and rRNA processingPotential rRNA (uridine-N3-)-methyltransferase activity (predicted)Phenylalanyl-tRNA synthetase-related function (domain occurs in a subset of these enzymes)
04
Disease associations
Currently, only weak or indirect associations with genetic conditions: CK syndrome, congenital hemidysplasia with ichthyosiform erythroderma and limb defectsNo strong or established disease role as a therapeutic target
05
Safety considerations
None described (not pursued as a therapeutic target)
06
Interacting drugs
None reported
1 more in the full profile.
07
Biomarkers
None clearly established; not clinically used as a biomarker
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