Ferric-chelate reductase 1 (FRRS1)

Ferric-chelate reductase 1 (FRRS1) is an enzyme belonging to the cytochrome b561 family that catalyzes the reduction of ferric iron (Fe(3+)) to ferrous iron (Fe(2+)), facilitating iron transport from endosomes to the cytoplasm[2][5][6]. In the central nervous system, the closely related protein FRRS1L acts as an AMPA receptor-associated auxiliary protein essential for the maintenance of normal excitatory synaptic transmission; loss-of-function mutations in FRRS1L lead to neurodevelopmental defects, epilepsy, and cognitive impairment[1][2]. FRRS1 may also be involved in cancer, where its dysregulation promotes tumor cell proliferation and survival[2]. The gene is located on chromosome 1 and is also known by the aliases SDFR2 and SDR2[3]. FRRS1 is not currently known to be directly targeted by any approved drugs and is not established as a clinical biomarker or drug target, though its biological roles suggest relevance for neurological and oncological conditions[2].

Other names

SDFR2SDR2SDR-2Stromal cell-derived receptor 2stromal cell-derived factor receptor 2 homologferric-chelate reductase 1-like (FRRS1L)