Target intelligence / Profile preview

Iron Ion (None)

Target
None
Molecular classification
Inorganic Ion, Metal Ion, Cofactor
01

Overview

Iron ions (Fe2+ and Fe3+) are essential inorganic ions that play crucial roles in various biological processes, including oxygen transport, electron transfer, and enzyme catalysis. They are not direct therapeutic targets in the traditional sense, but rather critical components of biological systems that are modulated by drugs. Iron homeostasis is tightly regulated, and imbalances can lead to various diseases, including iron deficiency anemia and iron overload disorders. Consequently, drugs are used to supplement iron, chelate excess iron, or indirectly manipulate iron metabolism.

Other names
Fe2+Ferrous IonIron(II) IonFe3+Ferric IonIron(III) IonFe1+Iron(I) Ion
02

Mechanism of action

Iron ions themselves are not drug targets. Rather, drugs interact with iron ions to supplement deficiencies, chelate excess, or manipulate iron homeostasis indirectly via other pathways.

03

Biological functions

Oxygen TransportElectron TransportEnzyme CofactorRedox Reactions
04

Disease associations

AnemiaIron DeficiencyHemochromatosisNeurodegenerative Diseases (e.g., Parkinson's)Infection (iron sequestration by pathogens)Chronic Kidney DiseasePhosphate Imbalance
05

Safety considerations

Iron Overload (Hemochromatosis, Hemosiderosis)Gastrointestinal Side Effects (Iron Supplements)Drug Interactions (e.g., with antacids, tetracyclines)Risk of Infection (iron as a nutrient for pathogens)
06

Interacting drugs

Iron Supplements (Ferrous Sulfate, Ferrous Gluconate, Ferric Citrate)

2 more in the full profile.

07

Biomarkers

Serum IronFerritinTransferrin SaturationHemoglobinHematocrit

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