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Ferriprotoporphyrin IX (None)
- Target
- None
- Molecular classification
- Porphyrin, Prosthetic Group
01
Overview
Ferriprotoporphyrin IX is the iron(III) complex of protoporphyrin IX, commonly referred to as heme B. It serves as a prosthetic group for hemoproteins and accumulates as a toxic byproduct during hemoglobin digestion in malaria parasites, making it a drug target for antimalarials. Antimalarial drugs such as chloroquine act by binding ferriprotoporphyrin IX and inhibiting its conversion into non-toxic hemozoin crystals within Plasmodium parasites. This leads to accumulation of toxic free heme species that damage parasite membranes via oxidative stress
- Other names
- HeminFerriprotoporphyrin IX chlorideHeme BProtohemeHematinFerriheme
02
Mechanism of action
Inhibition of hemozoin formation
03
Biological functions
Prosthetic group for hemoproteinsHemoglobin digestion byproduct (Plasmodium)Cofactor
04
Disease associations
Malaria
05
Interacting drugs
Chloroquine
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