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Ferritin
- Molecular classification
- Protein complex, Iron storage protein
01
Overview
Ferritin is a universal intracellular and extracellular protein complex that serves as the primary iron storage molecule. It stores iron in a soluble and non-toxic form and releases it in a controlled manner to maintain iron homeostasis. It is composed of 24 polypeptide subunits that self-assemble into a hollow spherical nanocage, allowing it to store up to approximately 4,500 iron ions. Ferritin levels are commonly measured via blood tests for diagnostic purposes related to iron levels, inflammation, and other diseases.
02
Biological functions
Iron storageIron homeostasisReactive oxygen species detoxification
03
Disease associations
Iron deficiency anemiaHemochromatosisHemosiderosisInflammationCancerAutoimmune disordersLiver diseaseRestless legs syndromeAdult-onset Still diseaseNeurodegenerative disorders
04
Biomarkers
Iron deficiencyIron overloadInflammationChronic diseases
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