Cell Death Pathway

Cell death pathways are a collection of tightly regulated molecular mechanisms that determine how and when cells die. These pathways are essential for maintaining tissue homeostasis, development, immune function, and the elimination of damaged or potentially harmful cells. The most well-characterized forms of cell death include apoptosis, necroptosis, pyroptosis, autophagic cell death, and ferroptosis. Dysregulation of these pathways contributes to diseases such as cancer, neurodegeneration, autoimmune disorders, and cardiovascular diseases.

Other names

Programmed Cell DeathRegulated Cell DeathApoptosisNecroptosisPyroptosisAutophagic Cell DeathFerroptosis

Modulation of caspase activity, regulation of Bcl-2 family proteins, inhibition of RIPK1/RIPK3 complex, induction or inhibition of autophagy, targeting gasdermin proteins.