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Ferroptosis Induction (N/A)
- Target
- N/A
- Molecular classification
- Cell Death Pathway, Oxidative Stress Pathway, Iron Metabolism Pathway
01
Overview
Ferroptosis induction refers to the process of triggering ferroptosis, a distinct form of regulated cell death that is iron-dependent and characterized by the accumulation of lipid peroxides and reactive oxygen species (ROS) within cells. It involves the disruption of cellular antioxidant defenses, leading to uncontrolled lipid peroxidation and ultimately cell death. Key players include iron, GPX4, System xc-, and enzymes involved in PUFA metabolism.
02
Mechanism of action
Inhibition of GPX4/GSH, inhibition of System xc-, modulation of iron metabolism, induction of lipid peroxidation
03
Biological functions
Cell DeathTumor SuppressionRegulation of Oxidative StressLipid Peroxidation
04
Disease associations
CancerNeurodegenerative diseaseIschemia-Reperfusion InjuryRadiation Therapy Resistance
05
Safety considerations
Off-target effects on normal tissuesToxicity due to lipid peroxidationDysregulation of antioxidant defenses
06
Interacting drugs
Erastin
2 more in the full profile.
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