Ferroptosis Pathway (Inhibitor)

Ferroptosis is a regulated, iron-dependent form of cell death characterized by the accumulation of lipid peroxides and reactive oxygen species (ROS). Inhibitors targeting the ferroptosis pathway are molecules or drugs that prevent this specific type of cell death, offering therapeutic potential in diseases where ferroptosis contributes to pathology, such as neurodegeneration, ischemic injury, and certain cancers.

Enhancing antioxidant defenses via upregulation or stabilization of GPX4/GSH system; Scavenging free radicals directly; Chelating intracellular iron to limit ROS production; Supporting alternative antioxidative systems such as FSP1-CoQ10-NAD(P)H axis