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Ferroptosis Pathway Stimulation
- Molecular classification
- Pathway
01
Overview
Ferroptosis is a regulated, non-apoptotic form of cell death characterized by the iron-dependent accumulation of lipid peroxides to lethal levels. Stimulation of the pathway involves inhibiting GPX4 or System Xc− function, increasing intracellular free iron, or enhancing enzymes involved in PUFA oxidation. This pathway is implicated in cancer biology, neurodegeneration, and cardiovascular diseases due to its association with oxidative stress and cell death.
02
Mechanism of action
Inhibition of GPX4; Inhibition of System Xc−; Increased labile iron; Enhanced PUFA oxidation
03
Biological functions
Cell deathOxidative stress responseLipid metabolism regulationIron metabolism regulation
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Off-target effects due to broad impact on cellular metabolismPotential for inducing unwanted cell death in healthy tissues
06
Interacting drugs
Erastin
1 more in the full profile.
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