Ferroptosis-related factors

Ferroptosis-related factors are a group of molecular components—including enzymes, transporters, metabolic regulators, iron transport proteins, and transcription factors—implicated in the initiation, regulation, and execution of ferroptosis[1][2][3][4][6][7][9]. Key factors include iron importers (e.g., transferrin receptor), iron storage proteins (e.g., ferritin), lipid metabolism enzymes (notably ACSL4, ALOX family), antioxidant pathways (such as glutathione peroxidase 4/GPX4, system x_c^-, and FSP1/CoQ10 axis), and regulators of glutamine and cysteine metabolism. Rather than representing a singular, defined molecular entity, "ferroptosis-related factors" encompass a network of molecules that together determine cellular sensitivity to ferroptosis and constitute potential points for therapeutic modulation in various diseases[1][2][7][9].

Other names

Ferroptosis modifiersFerroptosis regulatorsFerroptosis effectorsFactors involved in ferroptosis

Inhibition of glutathione peroxidase 4 (GPX4) to induce ferroptosis; Inhibition of cystine import via system x_c^- (SLC7A11); Iron chelation to prevent iron-dependent lipid peroxidation; Radical trapping to block lipid peroxidation