Ferroptosis-related proteins

Ferroptosis-related proteins are a diverse group of enzymes, transporters, and regulatory factors that collectively govern ferroptosis, a form of iron-dependent regulated cell death characterized by the accumulation of lipid peroxides [1.1.2, 1.2.1]. Key members include glutathione peroxidase 4 (GPX4), which neutralizes lipid hydroperoxides, and the cystine/glutamate transporter (SLC7A11), which provides the precursor for glutathione synthesis [1.3.1, 1.4.4]. Other critical proteins like ACSL4 and LPCAT3 facilitate the incorporation of polyunsaturated fatty acids into membranes, making them susceptible to oxidation [1.3.1, 1.3.2]. Dysregulation of these proteins is implicated in various diseases, including cancer, where inducing ferroptosis can eliminate therapy-resistant cells, and neurodegenerative or ischemic diseases, where inhibiting ferroptosis may prevent tissue damage [1.1.4, 1.1.5]. Pharmacological modulation of these proteins, using inducers like erastin or inhibitors like ferrostatin-1, represents a promising therapeutic strategy across multiple clinical indications [1.1.1, 1.3.1].

Other names

Ferroptosis regulatorsFerroptosis-associated proteinsFerroptosis pathway components

Modulation of lipid peroxidation, iron metabolism, and antioxidant defense systems to either induce or inhibit iron-dependent regulated cell death.