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Target intelligence / Profile preview
Ferry endosomal RAB5 effector complex subunit 3 (FERRY3)
- Target
- FERRY3
- Molecular classification
- Other (component of a multi-protein complex)
01
Overview
Ferry endosomal RAB5 effector complex subunit 3 is a cytoplasmic protein-coding gene found in humans, encoded by the C12orf4 gene. It is a critical part of the FERRY complex, which mediates the interaction between RAB5A, mRNA molecules, and ribosomes for endosomal mRNA transport. It plays a role in mast cell degranulation and endosomal localization of specific mRNAs, and is highly conserved across species. Variations in the gene are linked to autosomal recessive intellectual disability, but the protein is not currently established as a direct therapeutic or pharmacological target. It is classified as a component of a multi-protein effector complex, rather than as a receptor, enzyme, or similar druggable protein class[1][8].
- Other names
- FERRY3C12orf4Fy-3MRT66protein C12orf4FERY3 (occasionally)
02
Mechanism of action
None applicable
03
Biological functions
mRNA endosomal transportRegulation of mast cell degranulationProtein-mRNA/RAB5A interaction
04
Disease associations
Neurodevelopmental disorders (autosomal recessive intellectual disability)
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