Target intelligence / Profile preview

Fetal Hemoglobin (HbF)

Target: HbF
Molecular classification: Metalloprotein, Globulin

Overview

Fetal hemoglobin enables effective transfer and retention of maternal oxygen within fetal circulation due to its unique structure and high-affinity binding characteristics. Its expression pattern is developmentally regulated but can be therapeutically targeted in certain blood disorders where increased levels are beneficial.

Other names: Hemoglobin Fα2γ2

Mechanism of action

Pharmacological induction of HbF synthesis inhibits polymerization of sickle cell mutant β-globin

Biological functions

Oxygen transport

Disease associations

Beta-thalassemiaSickle cell disease

Biomarkers

HbF levels

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