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Fetal Hemoglobin Induction (HbF Induction)
- Target
- HbF Induction
- Molecular classification
- Gene Expression Regulation, Transcription factor modulation, Epigenetic modification
01
Overview
Fetal hemoglobin (HbF, α2γ2) induction is a therapeutic strategy that aims to increase the production of HbF in adults, particularly in patients with β-hemoglobinopathies like sickle cell disease and β-thalassemia. This is achieved through various mechanisms including epigenetic modification of γ-globin genes and modulation of transcription factors that regulate their expression.
- Other names
- HBG1/HBG2 gene reactivationGamma-globin gene expressionFetal hemoglobin upregulation
02
Mechanism of action
Reactivation/upregulation of HBG1/HBG2 genes encoding gamma globins through epigenetic modification (DNA/histone) or transcription factor modulation.
03
Biological functions
Oxygen transportErythropoiesisHemoglobin production
04
Disease associations
Sickle cell diseaseBeta-thalassemia
05
Safety considerations
MyelosuppressionTeratogenicityRisk of malignanciesCytotoxicityDrug resistance
06
Interacting drugs
Hydroxyurea
7 more in the full profile.
07
Biomarkers
HbF levelsγ-globin mRNA levelsBCL11A expressionZBTB7A expressionIKZF1 expression
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