Fez family zinc finger protein 2 (FEZF2)

Fez family zinc finger protein 2 (FEZF2) is a zinc finger transcription factor that acts as a master regulator of neocortical projection neuron identity during early corticogenesis, specifying corticospinal motor neurons and other subcerebral projection neurons by activating gene expression programs necessary for glutamatergic identity and axonal patterning. Loss of FEZF2 causes mis-specification of neuronal fates, whereas its ectopic expression can reprogram neurons toward subcerebral identities. FEZF2 functions as a transcriptional repressor, is highly expressed in the developing cerebral cortex, and plays essential roles in neuronal subtype specification, axonal guidance, and nervous system development. It is localized to the nucleus and implicated in both developmental neurobiology and certain neurodevelopmental diseases, including autism spectrum disorder and thymic dysplasia[1][2][6].

Other names

FEZLZNF312FKSG36FLJ10142TOFZfp312forebrain embryonic zinc finger-like protein 2zinc finger protein 312too fewforebrain embryonic zinc finger-like proteinFEZtestis tissue sperm-binding protein Li 80P