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Fgr proto-oncogene tyrosine-protein kinase (FGR)
- Target
- FGR
- Molecular classification
- Enzyme, Protein kinase, Tyrosine kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
FGR (Fgr proto-oncogene, Src family tyrosine kinase) is a non-receptor tyrosine-protein kinase and a member of the Src family of protein tyrosine kinases. It plays roles in immune cell signaling, regulating immune responses in neutrophils, monocytes, macrophages, and mast cells. FGR modulates cytoskeleton remodeling, phagocytosis, cell adhesion/migration, and is involved in IgE-mediated anaphylaxis. Overexpression or dysregulation may contribute to oncogenic processes or immune dysfunctions.
- Other names
- c-fgrSRC2feline Gardner-Rasheed sarcoma viral oncogene homolog
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
Signal transductionImmune response regulationCytoskeleton reorganizationCell adhesionCell migrationPhagocytosisProtein phosphorylation
04
Disease associations
CancerImmune dysregulationInflammation
05
Safety considerations
Potential for off-target effects due to kinase family similarityDysregulation can lead to oncogenesisInhibition may disrupt normal immune function
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