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Target intelligence / Profile preview
FHF complex subunit HOOK-interacting protein 2B (FHIP2B)
- Target
- FHIP2B
- Molecular classification
- Other (component of the FHF complex; functionally related to protein interaction/adaptor complexes)
01
Overview
FHF complex subunit HOOK-interacting protein 2B (FHIP2B) is a protein-coding gene with regulatory roles in cellular signaling pathways, notably activating MAPK/ERK and TGFB signaling[2][12][13]. It may modulate gene activity related to intestinal barrier integrity and immunoprotection, and potentially has a role in cell proliferation[2][12]. FHIP2B is associated with certain cancers, acting as a tumor marker in hepatocellular carcinoma and being linked to colon lymphoma[2][6]. It is classified as a member of a protein complex (FHF complex) but is not an enzyme, receptor, transporter, ion channel, or transcription factor. There are presently no known drugs directly targeting FHIP2B, nor is it established as a classic therapeutic target.
- Other names
- FAM160B2FLJ21801RAI16retinoic acid-induced protein 16
02
Biological functions
Activation of MAPK/ERK signaling pathwayActivation of TGFB signaling pathwayRegulation of genes involved in intestinal barrier function and immunoprotective inflammationPossible role in cell proliferation
03
Disease associations
Cancer (notably implicated as a tumor marker for hepatocellular carcinoma, associated with colon lymphoma)Other (involvement in hypotrichosis)
04
Biomarkers
Tumor marker for hepatocellular carcinoma
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