Fibrin (Factor Ia)

Fibrin, also known as Factor Ia, is a fibrous, non-globular protein that plays a crucial role in blood clotting (hemostasis). It is formed through the conversion of fibrinogen, a soluble plasma protein, by the action of the protease enzyme thrombin. This conversion and subsequent polymerization of fibrin is essential for wound healing and preventing excessive blood loss. Fibrin is the major component of blood clots, forming a mesh atop platelet plugs at wound sites to prevent blood loss. It also provides a scaffold for cell migration and tissue repair during the wound healing process. Abnormalities in fibrin formation or degradation are associated with various pathological conditions, including thrombosis, hemorrhagic disorders, cancer, and cardiovascular disease. Fibrin degradation products (FDPs), particularly D-dimer, are measured to detect conditions involving abnormal clot formation or dissolution.

Other names

Factor IaFibrin clot

Modulating fibrinogen levels or targeting fibrin-dependent interactions