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Fibrin P2 Epitope (Fibrin-P2)
- Target
- Fibrin-P2
- Molecular classification
- Epitope, Fibrinogen fragment
01
Overview
The Fibrin P2 epitope is a cryptic, pro-inflammatory sequence exposed on the fibrinogen γ chain (amino acids 377–395) after conversion of fibrinogen to insoluble fibrin by thrombin cleavage. This epitope is not accessible in soluble fibrinogen and becomes available only upon formation of cross-linked, insoluble fibrin. Upon exposure, the P2 epitope binds to CD11b/CD18 (complement receptor 3/CR3/Mac-1/αMβ2 integrin) and CD11c/CD18 (CR4/αXβ2 integrins) receptors found on microglia, macrophages, neutrophils, and dendritic cells, triggering innate immune activation and potentially contributing to neurodegenerative diseases.
- Other names
- Fibrin γ377-395
02
Mechanism of action
Blocks innate immune cell activation via CR3/CR4
03
Biological functions
Innate immune activationInflammatory responseMicroglial/macrophage activationCD11b/CD18 bindingCD11c/CD18 binding
04
Disease associations
Neurodegenerative diseasesAlzheimer's diseaseMultiple sclerosisParkinson's diseaseAmyotrophic lateral sclerosisNeuroinflammation
05
Safety considerations
Potential for off-target effectsImmunogenicity of antibodies
06
Interacting drugs
mAb 5B8
1 more in the full profile.
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