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Fibrinogen alpha chain
- Molecular classification
- Glycoprotein, Coagulation factor
01
Overview
The fibrinogen alpha chain is a protein encoded by the FGA gene in humans and is a component of fibrinogen. Upon vascular injury, thrombin cleaves fibrinogen to form insoluble fibrin, which polymerizes to create the structural framework for blood clots. Mutations or deficiencies can result in various bleeding or clotting disorders. It also interacts with tissue plasminogen activator, which is important for clot breakdown.
- Other names
- FGAFibrinogen alpha-A chainFibrinogen alpha chain precursor
02
Mechanism of action
Targeted by drugs that interfere with fibrin clot formation or promote clot breakdown.
03
Biological functions
HemostasisWound healingCell adhesionCell spreadingMitogenesis
04
Disease associations
DysfibrinogenemiaHypofibrinogenemiaAfibrinogenemiaRenal amyloidosisBleeding disordersThrombosis
05
Safety considerations
Risk of bleedingRisk of thrombosisImmunogenicity of therapeutic fibrinogen products
06
Biomarkers
Fibrinogen levels can be used as a biomarker for cardiovascular risk and inflammatory conditions.
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