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Target intelligence / Profile preview
Fibrinogen Beta Chain (FGB)
- Target
- FGB
- Molecular classification
- Protein subunit, Glycoprotein
01
Overview
The fibrinogen beta chain (FGB) is one of the three polypeptide chains (alpha, beta, gamma) composing the fibrinogen complex, a crucial glycoprotein in blood coagulation and wound healing. Encoded by the FGB gene on chromosome 4, it is cleaved by thrombin to form fibrin. Its interactions modulate platelet aggregation, inflammation, and immune responses, influencing clot structure and fibrinolysis. Mutations lead to conditions like afibrinogenemia and dysfibrinogenemia, manifesting as abnormal bleeding or increased thrombosis risk.
02
Mechanism of action
N/A
03
Biological functions
HemostasisWound healingBlood coagulationCell adhesionImmune responseInflammation
04
Disease associations
AfibrinogenemiaDysfibrinogenemiaHypodysfibrinogenemiaThrombosisBleeding disorders
05
Safety considerations
Thrombotic riskBleeding risk
06
Biomarkers
Fibrinogen levels as a marker for inflammation or coagulation disorders
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