Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fibrinogen Gamma Chain (FGG)
- Target
- FGG
- Molecular classification
- Glycoprotein, Coagulation factor
01
Overview
The fibrinogen gamma chain is one of the three polypeptide chains (alpha, beta, and gamma) that constitute fibrinogen, a crucial blood-borne glycoprotein involved in hemostasis. Encoded by the FGG gene, the gamma chain plays a vital role in blood clot formation by mediating platelet binding and Factor XIIIa cross-linking. Alternative splicing produces γA and γ' isoforms, with their relative levels influencing cardiovascular disease risk. Mutations in the FGG gene can lead to dysfibrinogenemia, hypofibrinogenemia, and thrombophilia.
- Other names
- Fibrinogen gamma-A chainFibrinogen gamma chainFibrinogen gamma prime chain
02
Biological functions
Blood coagulationPlatelet aggregationCell adhesionWound healingHemostasis
03
Disease associations
DysfibrinogenemiaHypofibrinogenemiaThrombophiliaCoronary artery diseaseDeep vein thrombosis
04
Safety considerations
Potential for thrombosis or bleeding disorders due to altered fibrinogen function
05
Biomarkers
Fibrinogen gamma-A/gamma-prime ratio (γA/γ')
Beyond the preview
Go deeper on Fibrinogen Gamma Chain (FGG).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fibrinogen Gamma Chain (FGG).