Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fibrinogen Receptor (GPIIb/IIIa)
- Target
- GPIIb/IIIa
- Molecular classification
- Integrin, Receptor
01
Overview
The fibrinogen receptor, also known as glycoprotein IIb/IIIa (GPIIb/IIIa) or integrin αIIbβ3, is the most abundant integrin on the surface of platelets. It plays a central role in hemostasis by mediating platelet aggregation through its ability to bind fibrinogen and other adhesive proteins. This receptor is a calcium-dependent heterodimer composed of two subunits: GPIIb (integrin αIIb) and GPIIIa (integrin β3). Abnormalities in this receptor's function lead to major bleeding disorders such as Glanzmann's thrombasthenia, while excessive activity contributes to pathological thrombosis, making it a critical target for antithrombotic therapies.
- Other names
- Glycoprotein IIb/IIIaIntegrin αIIbβ3
02
Mechanism of action
Inhibition of platelet aggregation by blocking fibrinogen and vWF binding to GPIIb/IIIa.
03
Biological functions
Platelet adhesionPlatelet aggregationHemostasisCell signaling
04
Disease associations
Glanzmann's thrombastheniaThrombosisCardiovascular disease
05
Safety considerations
Bleeding risk
06
Interacting drugs
Monoclonal antibodies targeting GPIIb/IIIa
1 more in the full profile.
Beyond the preview
Go deeper on Fibrinogen Receptor (GPIIb/IIIa).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fibrinogen Receptor (GPIIb/IIIa).