Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fibrinogen silencer-binding protein (FSBP)
- Target
- FSBP
- Molecular classification
- Transcription factor, DNA-binding protein (contains Myb/SANT-like DNA-binding domain)
01
Overview
Fibrinogen silencer-binding protein (FSBP) is a nuclear transcription factor that down-regulates expression of the gamma chain of fibrinogen, a plasma glycoprotein essential for coagulation. FSBP is implicated in feedback regulation of inflammatory and cytokine signaling pathways, particularly the JAK/STAT axis. In cancer biology, FSBP acts as a suppressor of tumor migration and metastasis by inhibiting the JNK pathway. There is evolutionary conservation between FSBP in humans and the Drosophila gene Apontic (Apt), with functional relevance in developmental biology and cell differentiation. FSBP may have roles in diseases such as cancer and cardiovascular conditions related to fibrinogen levels
- Other names
- FSBPFibrinogen silencer binding proteinFSBP_HUMANGene Symbol: FSBP
02
Mechanism of action
Transcriptional repression via DNA binding and interaction with transcriptional machinery\nSuppression of JNK signaling pathway to inhibit metastasis
03
Biological functions
Transcriptional repression (of the fibrinogen gamma chain gene)Regulation of gene expressionNegative feedback in cytokine and growth factor signaling (including JAK/STAT pathway)Suppression of tumor metastasis (inhibits JNK pathway)
04
Disease associations
Cancer (suppresses tumor cell migration and metastasis)Cardiovascular disease (involved in regulation of fibrinogen levels, which are linked to vascular disease risk)Aplastic anemia (reported disease association)Bloom syndrome (reported disease association)
05
Biomarkers
Expression or activity of FSBP may serve as a biomarker for tumor migration/metastasis riskFibrinogen gamma chain gene expression profiles in tissue samples
Beyond the preview
Go deeper on Fibrinogen silencer-binding protein (FSBP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fibrinogen silencer-binding protein (FSBP).