Fibroblast Activation and Proliferation (N/A)

Fibroblast activation and proliferation are key processes in tissue repair, fibrosis, and pathological remodeling. Quiescent fibroblasts become activated in response to injury or inflammation, transitioning into myofibroblasts characterized by increased proliferation, migration, ECM production, and expression of markers like αSMA and FAP. These processes are regulated by growth factors (e.g., TGFβ, PDGF), signaling cascades (e.g., mTOR, TRP channels), and mechanical stress. Dysregulation of fibroblast activation/proliferation contributes to diseases such as fibrosis, cancer, and chronic inflammation.

Other names

Myofibroblast differentiationFibroblast proliferationFibroblast activation

Varies depending on the specific target (e.g., inhibition of TGFβ signaling, blockade of PDGFR activation, etc.)