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Target intelligence / Profile preview
Fibroblast Growth Factor 1 (FGF-1)
- Target
- FGF-1
- Molecular classification
- Fibroblast Growth Factors
01
Overview
Fibroblast Growth Factor 1 (FGF-1) is a member of the FGF family that acts as a potent mitogen for fibroblasts, endothelial cells, and other cell types. It plays key roles in tissue repair, angiogenesis, and immune modulation. Its dysregulation is implicated in cancer progression.
- Other names
- aFGFECGFFGFA
02
Mechanism of action
Binds heparan sulfate proteoglycans/FGFRs to activate MAPK pathway.
03
Biological functions
Cell proliferationCell migrationAngiogenesisWound healingImmune response
04
Disease associations
CancerInflammationRheumatoid ArthritisTumorigenesis
05
Safety considerations
Overexpression implicated in pathological angiogenesis
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