Fibroblast growth factor 10 (FGF10)

Fibroblast growth factor 10 (FGF10) is a secreted protein member of the fibroblast growth factor family functioning primarily as a paracrine signaling growth factor. It is crucial for embryonic development, especially for limb and branching organ formation (e.g., lung, glands), and in adult tissue repair and epithelial-mesenchymal signaling. FGF10 signals through its high-affinity receptor FGFR2b, activating intracellular kinase cascades (ERK1/2, PI3K/AKT) to promote proliferation, differentiation, and migration. Alterations in FGF10 expression or function are implicated in developmental disorders (such as LADD syndrome), chronic diseases (e.g., COPD), and oncogenesis in several cancer types. No approved drugs specifically target FGF10 directly, though FGFR inhibitors affect its pathway and recombinant FGF10 is under investigation for regenerative medicine[1][2][4][6][7].

Other names

FGF10FGF-10Keratinocyte growth factor 2KGF2LADD3

For drugs targeting FGF10 or its pathway, the principal mechanisms involve: - Inhibition of FGFR2b (the primary receptor for FGF10) by small-molecule tyrosine kinase inhibitors - Recombinant FGF10 acting as an agonist to promote tissue repair and regeneration