Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Fibroblast Growth Factor 19 (FGF19)
- Target
- FGF19
- Molecular classification
- Fibroblast Growth Factor (FGF) Family, Endocrine Hormone
01
Overview
Fibroblast Growth Factor 19 (FGF19) is an endocrine hormone primarily produced in the ileum in response to bile acid absorption. It regulates bile acid synthesis, glucose metabolism, lipid metabolism, and energy homeostasis. FGF19 acts mainly on hepatocytes in the liver via FGFR4 and β-Klotho, leading to downregulation of CYP7A1 and decreased bile acid synthesis. It also influences cell survival/proliferation and bone mineralization. Dysregulation of FGF19 is implicated in diseases such as chronic bile acid diarrhea, metabolic disorders, liver disease, and HCC. The mouse ortholog is FGF15.
- Other names
- FGF-19
02
Mechanism of action
Ileal secretion after FXR stimulation -> Circulation -> Hepatic action via FGFR4/β-Klotho complex -> Downregulation of CYP7A1 -> Decreased new bile acid synthesis.
03
Biological functions
Bile acid synthesis regulationGlucose metabolism regulationLipid metabolism regulationEnergy homeostasis regulationCell proliferationOrganogenesis
04
Disease associations
Chronic Bile Acid DiarrheaMetabolic DisordersLiver DiseaseHepatocellular Carcinoma (HCC)Bone Health
05
Safety considerations
Overexpression linked to hepatocellular carcinoma (HCC)Inhibition causes severe diarrhea and liver toxicity
Beyond the preview
Go deeper on Fibroblast Growth Factor 19 (FGF19).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Fibroblast Growth Factor 19 (FGF19).