Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Basic fibroblast growth factor (bFGF)
- Target
- bFGF
- Molecular classification
- Fibroblast Growth Factor family, Growth Factor
01
Overview
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a potent mitogenic and cell survival factor involved in various biological processes including embryonic development, cell proliferation, differentiation, migration, morphogenesis, tissue repair/regeneration, tumor growth/invasion, and angiogenesis. It binds to FGFRs, activating downstream signaling pathways.
- Other names
- FGF2Fibroblast growth factor 2
02
Mechanism of action
bFGF exerts its effects by binding to specific fibroblast growth factor receptors (FGFRs), which are tyrosine kinase receptors. Binding activates several intracellular signaling pathways: RAS/MAPK, PI3K/AKT, PLCγ, STAT pathways.
03
Biological functions
Cell survivalCell proliferationCell differentiationCell migrationAngiogenesisTissue repairTissue regenerationEmbryonic developmentMorphogenesis
04
Disease associations
CancerWound healingMyocardial InfarctionAnxiety (in animal studies)
05
Safety considerations
Dysregulation can contribute to pathological conditions like cancer progression due to excessive stimulation of angiogenesis/cell proliferation.
Beyond the preview
Go deeper on Basic fibroblast growth factor (bFGF).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Basic fibroblast growth factor (bFGF).