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Target intelligence / Profile preview
Fibroblast Growth Factor 21 (FGF21)
- Target
- FGF21
- Molecular classification
- Fibroblast Growth Factor family, Endocrine hormone, Hepatokine
01
Overview
Fibroblast growth factor 21 (FGF21) is an atypical member of the fibroblast growth factor family, functioning primarily as an endocrine hormone. It is mainly secreted by the liver and plays a crucial role in regulating glucose and lipid metabolism, enhancing insulin sensitivity, and modulating energy expenditure. Elevated levels are observed in metabolic disorders like obesity and type 2 diabetes, making it a promising therapeutic target for these conditions.
- Other names
- FGF-21
02
Mechanism of action
Pharmacologic administration of recombinant FGF21 has shown: - Enhanced insulin sensitivity - Decreased triglycerides - Weight loss in animal models
03
Biological functions
Metabolic regulationGlucose uptake/oxidationLipid oxidationKetogenesisInsulin sensitivity enhancementEnergy expenditure regulationThermogenesis stimulationModulation of simple sugar intake preferences
04
Disease associations
ObesityType 2 Diabetes MellitusNonalcoholic fatty liver disease (NAFLD)
05
Safety considerations
Potential resistance at target tissuesBone loss (in animal studies)Blocks somatic growth (in animal studies)
06
Interacting drugs
Recombinant FGF21
07
Biomarkers
Circulating FGF21 levelsrs838133 (FGF21 gene)
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