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Target intelligence / Profile preview
Fibroblast growth factor 21–Fibroblast growth factor receptor 1c complex (FGF21–FGFR1c)
- Target
- FGF21–FGFR1c
- Molecular classification
- Receptor complex, Tyrosine kinase receptor complex, Endocrine fibroblast growth factor receptor complex
01
Overview
- Other names
- FGF21-FGFR1c-beta-Klotho complexFGF21-FGFR1c-KLB complexFGF21 receptor complexFGF21-FGFR1c signaling complex
02
Mechanism of action
Agonism of the FGFR1c-beta-Klotho complex, which induces receptor dimerization and subsequent activation of the intracellular tyrosine kinase domains, leading to downstream signaling through the MAPK/ERK and PI3K/Akt pathways [2, 14].
03
Biological functions
Metabolic regulationGlucose homeostasisLipid metabolismEnergy expenditureInsulin sensitivityThermogenesisKetogenesisRegulation of sugar and alcohol intake
04
Disease associations
Metabolic dysfunction-associated steatohepatitis (MASH)ObesityType 2 DiabetesDyslipidemiaMetabolic syndromeAlcohol use disorder
05
Interacting drugs
Efruxifermin
6 more in the full profile.
06
Biomarkers
Adiponectin [1}
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