Fibroblast growth factor 3 (FGF3)

Fibroblast growth factor 3 (FGF3) is a member of the FGF family, which comprises secreted signaling proteins essential for cell growth, proliferation, differentiation, and development. FGF3 is especially critical in embryonic development, where it triggers chemical signals influencing the formation and maturation of structures such as the inner and outer ears and teeth. Mutations in FGF3 are linked to congenital disorders, notably causing deafness and dental malformations (LAMM syndrome). FGF3 also possesses oncogenic potential due to its proto-oncogene classification, and aberrant expression may be implicated in certain cancers[6].

Other names

FGF-3INT2INT-2 proto-oncogene proteinHBGF-3Heparin-binding growth factor 3Proto-oncogene Int-2V-INT2 murine mammary tumor virus integration site oncogene homolog

Drugs that target the FGF/FGFR pathway (such as FGFR inhibitors) typically act by blocking the receptor's kinase activity or ligand binding to inhibit downstream signaling, though these do not target FGF3 directly[7].