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Target intelligence / Profile preview
Fibroblast Growth Factor 4 (FGF4)
- Target
- FGF4
- Molecular classification
- Fibroblast Growth Factor Family, Signaling molecule
01
Overview
Fibroblast Growth Factor 4 (FGF4) is a protein that belongs to the fibroblast growth factor family and plays a critical role during embryonic development, especially in cell survival, proliferation, and patterning. It is associated with oncogenic transforming activity and is closely located near another oncogenic gene (FGF3). Targeting FGF4 ligands or FGFR receptors has become an area of interest for anticancer drug development.
02
Mechanism of action
Targeting FGF4 ligands or FGFR receptors
03
Biological functions
Cell survivalCell proliferationPatterningEmbryonic developmentLimb bud outgrowthOrgan patterningTissue repair
04
Disease associations
CancerDevelopmental abnormalitiesTumorigenesis
05
Safety considerations
Oncogene activity when overexpressed or dysregulatedInvolvement across multiple developmental pathways
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