Fibroblast growth factor 6 (FGF6)

Fibroblast growth factor 6 (FGF6) is a member of the fibroblast growth factor family, acting as a cytokine and growth factor with key roles in cell proliferation, survival, and differentiation, especially in skeletal muscle regeneration and myogenic lineage commitment[1][2][5]. FGF6 is primarily expressed in muscle tissue, where it promotes expansion of muscle satellite cells and enhances regenerative potential, but it also has important systemic effects, such as modulating adipocyte thermogenesis and influencing bone remodeling by stimulating both osteoblast and osteoclast activity[2]. Dysregulation or aberrant expression of FGF6 is associated with tumorigenesis (notably in bladder cancer and hematologic malignancies), altered energy metabolism, and impaired tissue repair. FGF6 acts through binding and activating specific FGF receptors (FGFRs), resulting in complex downstream signaling that balances proliferation, differentiation, and tissue-specific functions[1][5][2].

Other names

FGF6FGF-6HST2HST-2HSTF2HSTF-2HBGF-6Heparin secretory-transforming protein 2Heparin-binding growth factor 6

Activation or modulation of fibroblast growth factor receptors (FGFRs), leading to downstream mitogenic, cell survival, and differentiation signaling pathways in responsive cells[5][2][1]