Fibroblast growth factor 8 (FGF8)

Fibroblast growth factor 8 (FGF8) is a secreted signaling protein belonging to the fibroblast growth factor family, with vital roles in embryonic development, organogenesis, cell proliferation, differentiation, and tissue repair[1][3][7]. FGF8 is particularly crucial for neural and limb development, midbrain-hindbrain patterning, and the emergence of gonadotropin-releasing hormone neurons, and it signals through fibroblast growth factor receptors (primarily FGFR1) to mediate its effects[1][3][7]. Abnormal FGF8 activity or mutations are linked to congenital disorders such as Kallmann syndrome and various cancers, making it a potential, albeit challenging, therapeutic target in oncology, skeletal disease, and endocrinology[1][3][5].

Other names

Fibroblast growth factor 8FGF8AIGFFGF-8HBGF-8androgen-induced growth factorheparin-binding growth factor 8HH6KAL6

FGFR inhibitors: block FGF8-induced receptor activation and downstream signaling. Experimental antibodies or ligand traps: block FGF8 binding to its receptor[5].