Fibroblast growth factor 9 (FGF9)

Fibroblast growth factor 9 (FGF9) is a secreted, heparin-binding growth factor belonging to the FGF family. It possesses broad mitogenic and cell survival activities, is a key regulator of embryonic development (including sex, lung, and skeletal patterning), tissue repair, cell proliferation, migration, and morphogenesis, and is especially important in glial cell development. FGF9 is produced by neurons and activated hepatic stellate cells and exerts its biological effects primarily through binding to and activating fibroblast growth factor receptors (FGFRs). Dysregulation of FGF9 is linked to cancer progression (notably hepatocellular carcinoma), resistance to cancer therapies, and disorders such as schizophrenia, where it has potential utility as a biomarker for diagnosis and monitoring

Other names

FGF-9GAF (Glia-activating factor)HBGF-9 (Heparin-binding growth factor 9)HBFG-9SYNS3Glia-activating factorHeparin-binding growth factor 9MGC119914MGC119915

FGFR inhibitor: Blocks downstream signaling of receptors activated by FGF9 (e.g., BGJ398 blocks FGFR1/2/3 mediated proliferative signals); Induction of resistance: FGF9 can induce resistance to kinase inhibitors like sorafenib in cancer cells by activating survival pathways