Fibroblast growth factor binding protein 1 (FGFBP1)

Fibroblast growth factor binding protein 1 (FGFBP1) is a secreted, extracellular carrier protein that binds fibroblast growth factors (FGFs), particularly FGF-1 and FGF-2, facilitating their release from the extracellular matrix and potentiating their mitogenic, angiogenic, and cell migration-inducing activities on target cells. FGFBP1 plays a crucial role in tissue repair, wound healing, and the pathophysiology of diverse cancers by acting as an "angiogenic switch" and enhancing tumor progression through FGF-driven signaling. FGFBP1 also modulates immune-related pathways and interacts with immune checkpoint proteins like PD-L1, influencing tumor microenvironment and immune escape. In cardiovascular biology, FGFBP1 sensitizes blood vessels to angiotensin II, impacting vascular tone and elevating blood pressure through FGF-dependent MAPK signaling. Its expression is upregulated in various pathological states, including multiple cancer types, inflammatory lesions, and hypertension, and it is being evaluated as a biomarker for prognosis and therapeutic responsiveness.

Other names

Fibroblast growth factor-binding protein 1FGFBPFGF-BPFGF-BP1FGFBP-1HBP1717 kDa HBGF-binding protein17 kDa heparin-binding growth factor-binding proteinFGF-binding protein 1heparin-binding growth factor binding protein

In cancer and angiogenesis, FGFBP1 enhances release and activity of immobilized fibroblast growth factors (FGFs), potentiating FGF signaling and oncogenic pathways; in cardiovascular disease, it sensitizes vessels to angiotensin II via FGF and MAPK signaling crosstalk