Fibroblast growth factor-binding protein 3 (FGFBP3)

Fibroblast growth factor-binding protein 3 (FGFBP3) is a secreted chaperone protein that binds and mobilizes fibroblast growth factors, particularly FGF2, from extracellular matrix storage, enhancing their bioavailability and receptor signaling activity[3][7]. FGFBP3 acts upstream of or within the fibroblast growth factor receptor pathway and positively regulates vascular permeability and metabolic regulation. It has structural domains for heparin and FGF binding and is localized in the extracellular region[3][5]. FGFBP3 modulates metabolic pathways, including lipid and glucose homeostasis, demonstrated by animal model studies showing effects on hepatic steatosis, hyperglycemia, and weight gain[5]. FGFBP3 is implicated in processes such as development, neural maintenance, tissue repair, tumorigenesis, and angiogenesis, and interacts with members of the FGF family to influence these pathways[3][7]. While not currently a direct drug target, its role in modulating FGF signaling positions it as a molecule of interest in cancer biology and metabolic diseases.

Other names

FGFBP3C10orf13PSEC0101FGF-BP3FGFBP-3MGC39320fibroblast growth factor-binding protein 3

Not available/applicable; FGFBP3 is not a direct target of approved pharmacologic agents.