Fibroblast growth factor family member (FGF (for individual members, e.g., FGF1, FGF2))

The **fibroblast growth factor family** comprises a group of structurally related polypeptides that function as potent regulators of cell proliferation, differentiation, migration, tissue maintenance, wound repair, angiogenesis, embryonic development and endocrine signaling. In humans there are 22–23 known members (designated FGF1 through FGF23), most of which act via binding to four transmembrane tyrosine kinase receptors called fibroblast growth factor receptors (FGFRs). Some members have paracrine or endocrine functions while others act intracellularly without engaging surface receptors. Mutations or dysregulation within this family are implicated in diverse pathologies including cancer progression/metastasis, cardiovascular disease risk modulation, skeletal disorders such as osteoarthritis/hypophosphatemia and neurodegenerative conditions like Parkinson’s disease. Because the term "fibroblast growth factor family member" is generic rather than specifying an individual protein target within this large group—each with distinct biological activities—it should be replaced with a precise name for accurate scientific communication and therapeutic targeting purposes.[1][2][3][4]

Other names

Fibroblast growth factorsFGFsHeparin-binding growth factors

Varies by drug; typically involves inhibition of the interaction between FGFs and their receptors (FGFRs), blocking downstream signaling pathways involved in cell proliferation, survival, angiogenesis.