Target intelligence / Profile preview

Fibroblast Growth Factor Ligand (FGF)

Target: FGF
Molecular classification: Polypeptide growth factor, Ligand, Secreted protein

Overview

Fibroblast growth factors (FGFs) are a family of polypeptide growth factors that regulate cellular processes such as proliferation, differentiation, migration, morphogenesis, and patterning. In humans, there are 18 secreted FGF ligands that interact with four main fibroblast growth factor receptors (FGFRs).

Other names: FGF LigandFibroblast Growth Factor

Mechanism of action

FGF ligands bind to FGFRs, inducing receptor dimerization and autophosphorylation, activating downstream signaling pathways like RAS-MAPK, PI3K-AKT, PLCγ, and STAT.

Biological functions

Cell proliferationCell differentiationMigrationMorphogenesisPattern formationAngiogenesisEmbryonic developmentMetabolic regulationNeurotrophic effectsTissue repairMaintenance of progenitor cellsWound healingTissue maintenance

Disease associations

Developmental disordersCraniofacial abnormalitiesHypogonadotropic hypogonadism/Kallmann syndromeAnosmiaTumorigenesis/Cancer progressionBone disorders

Safety considerations

Disrupted regulation may lead to bone disorders, tumor formation, and progression due to altered control over cell proliferation, differentiation, and angiogenesis.Mutations in FGF ligands can disrupt normal signaling and lead to disease.

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