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Target intelligence / Profile preview
Fibroblast Growth Factor Ligands (FGFs)
- Target
- FGFs
- Molecular classification
- Polypeptide growth factors, Secreted protein, Ligand
01
Overview
Fibroblast growth factor ligands (FGFs) are a family of polypeptide growth factors that regulate cell proliferation, differentiation, migration, morphogenesis, and tissue patterning. There are 18 canonical FGF ligands in humans that bind and activate fibroblast growth factor receptors (FGFRs). These ligands play crucial roles in embryonic development, tissue repair, and angiogenesis. Aberrant expression or activation of FGFs is implicated in developmental disorders and tumorigenesis, making them important drug targets.
- Other names
- FGF ligand familyFGF1FGF2FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGF10FGF16FGF17FGF18FGF19FGF20FGF21FGF22FGF23
02
Mechanism of action
Activation of FGFRs leading to downstream signaling cascades (RAS/MAPK, PI3K/AKT, PLCγ)
03
Biological functions
Cell proliferationCell differentiationCell migrationMorphogenesisTissue patterningEmbryonic developmentAngiogenesisWound healingTissue repairSurvival
04
Disease associations
Developmental disordersCancerTumorigenesisSkeletal development disordersCraniofacial disorders
05
Safety considerations
Aberrant activation can lead to tumorigenesisPotential developmental issues
06
Interacting drugs
Small molecule inhibitors targeting FGF/FGFR axis
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