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Fibroblast growth factor receptor–beta-Klotho complex (FGFR–β-Klotho complex)
- Target
- FGFR–β-Klotho complex
- Molecular classification
- Receptor (heterodimeric/co-receptor system), Tyrosine kinase receptor family (for FGFR component), Single-pass transmembrane protein (for beta-Klotho/KLB component), Endocrine hormone co-receptor
01
Overview
The Fibroblast growth factor receptor–beta-Klotho complex (FGFR–β-Klotho complex) is a well-established therapeutic target, particularly in metabolic and endocrine disorders. It is also sometimes referred to as FGFR–KLB complex. The name accurately describes the functional signaling unit, which acts as a heterodimeric co-receptor system for Fibroblast Growth Factors (FGFs). This complex plays a crucial role in signal transduction and is involved in the regulation of various metabolic processes, including glucose and lipid homeostasis. The FGFR component is a tyrosine kinase receptor, while beta-Klotho (KLB) functions as a single-pass transmembrane co-receptor.
- Other names
- FGFR–KLB complexFibroblast growth factor receptor and beta-Klotho co-receptor complexFGF21 receptor complex (when referring to FGF21 signaling)FGF19/FGF21/FGF23 receptor complexes (context-dependent)
02
Biological functions
Signal transductionRegulation of metabolism, including glucose and lipid homeostasis
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