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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 1
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
Fibroblast growth factor receptor 1 (FGFR1) is a cell-surface receptor tyrosine kinase that plays a central role in regulating key biological processes, including cell division, growth, differentiation, migration, survival, angiogenesis, wound healing, and embryonic development. It mediates cellular responses to extracellular signals by binding specific members of the FGF family, triggering downstream signaling cascades involved in cell proliferation, differentiation, migration, survival, angiogenesis, and embryonic development. Aberrant activation of FGFR1 can drive tumorigenesis, making it a target for small-molecule inhibitors targeting the tyrosine kinase activity.
- Other names
- basic fibroblast growth factor receptor 1fms-related tyrosine kinase-2Pfeiffer syndrome proteinCD331
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalAngiogenesisEmbryonic developmentSignal transduction
04
Disease associations
CancerPfeiffer syndromeClonal eosinophilias
05
Safety considerations
Adverse events associated with tyrosine kinase inhibitorsResistance mechanisms to targeted therapies
06
Interacting drugs
Small-molecule inhibitors targeting FGFR1 tyrosine kinase activity
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