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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 1c (FGFR1c)
- Target
- FGFR1c
- Molecular classification
- Receptor Tyrosine Kinase, Receptor, Single-pass transmembrane receptor
01
Overview
Fibroblast growth factor receptor 1c (FGFR1c) is an isoform of the FGFR1 protein, a receptor tyrosine kinase involved in cell signaling related to development, tissue homeostasis, and disease. It acts as a cell-surface receptor for fibroblast growth factors (FGFs), activating downstream signaling cascades that regulate cell proliferation, differentiation, and migration. FGFR1c is implicated in various cancers and developmental disorders, making it a target for therapeutic intervention.
- Other names
- FGFR1 IIIcFGFR-1c
02
Mechanism of action
Inhibition of FGFR1c tyrosine kinase activity, blocking downstream signaling pathways involved in cell proliferation, survival, and migration.
03
Biological functions
Cell proliferationCell differentiationCell migrationEmbryonic developmentSignal transductionSkeletogenesisNeuron survivalNeuron migration
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
On-target toxicity affecting normal FGFR1c functionOff-target effects due to promiscuity with other FGFR family membersDevelopment of resistance
06
Interacting drugs
FGFR inhibitors
2 more in the full profile.
07
Biomarkers
FGFR1 expression levels in tumor tissueFGFR1 mutations
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