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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 2 (FGFR2)
- Target
- FGFR2
- Molecular classification
- Receptor, Receptor tyrosine kinase
01
Overview
Fibroblast Growth Factor Receptor 2 (FGFR2), also known as CD332, is a receptor tyrosine kinase encoded by the FGFR2 gene on human chromosome 10. It is a member of the fibroblast growth factor receptor family, which plays critical roles in embryonic development, tissue repair, and cellular signaling. Upon FGF binding, FGFR2 dimerizes, activating its tyrosine kinase activity and initiating downstream signaling pathways like MAPK/ERK, PI3K-AKT, PLCγ, and STAT. Aberrant expression or mutations in FGFR2 are associated with congenital disorders and cancer.
- Other names
- CD332
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell divisionCell growthCell differentiationBone development/remodelingAngiogenesisWound healingEmbryonic patterningSignal transductionSelf-renewal of neuronal precursorsSynaptic terminal formation
04
Disease associations
LADD syndromeCancerDevelopmental disorders
05
Safety considerations
Abnormal signaling linked to disease statesConstitutive activation or impaired normal maturation/degradation processes due to mutations
06
Interacting drugs
Small-molecule FGFR inhibitors
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