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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 2c (None)
- Target
- None
- Molecular classification
- Receptor tyrosine kinases, Receptor
01
Overview
Fibroblast Growth Factor Receptor 2 (FGFR2) is a receptor tyrosine kinase that binds fibroblast growth factors (FGFs). The FGFR2c isoform is an alternative splice variant predominantly expressed in mesenchymal tissues. It plays critical roles in embryonic development, tissue repair, and angiogenesis. Upon FGF binding, FGFR2c activates intracellular signaling pathways, including Ras/MEK/MAPK and PI3K/Akt, leading to cell proliferation, differentiation, migration, and survival. Dysregulation or mutation of FGFR2c has been implicated in various cancers and developmental disorders. Small-molecule inhibitors targeting the kinase domain have been developed for cancer therapy.
- Other names
- FGFR2cCD332
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalAngiogenesisWound healingMitogenesisSignal transduction
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Aberrant activationAltered ligand specificity
06
Interacting drugs
Erdafitinib
1 more in the full profile.
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