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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 3 (FGFR3)
- Target
- FGFR3
- Molecular classification
- Receptor, Tyrosine Kinase, Fibroblast Growth Factor Receptor Family
01
Overview
Fibroblast Growth Factor Receptor 3 (FGFR3) is a transmembrane receptor tyrosine kinase that plays a crucial role in regulating cell growth, differentiation, and development. It is involved in various processes including bone growth, angiogenesis, and tumorigenesis. Mutations in FGFR3 are associated with skeletal dysplasias like achondroplasia and cancers such as bladder urothelial carcinoma. Targeting FGFR3 is of therapeutic interest, with drugs like erdafitinib showing efficacy against specific mutations.
- Other names
- CD333
02
Mechanism of action
Tyrosine kinase inhibitors, FGFR inhibitors
03
Biological functions
Cell proliferationCell differentiationAngiogenesisWound healingEmbryonic developmentRegulation of bone growthSignal transduction
04
Disease associations
AchondroplasiaHypochondroplasiaBladder urothelial carcinomaCancerSkeletal dysplasias
05
Safety considerations
Potential for off-target effects due to shared homology with other kinasesResistance development to inhibitorsSkeletal toxicities
06
Interacting drugs
Erdafitinib
07
Biomarkers
FGFR3 mutations (e.g., S249C, Y373C, G370C, R248C)
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