Fibroblast growth factor receptor 3 pseudogene (FGFR3P)

This gene, ENSG00000237026, codes for a pseudogene that is highly similar in sequence to the fibroblast growth factor receptor 3 (FGFR3) gene, but does not produce a functional protein. Pseudogenes are non-functional segments of DNA that arise from once-functional genes by mutation or duplication. Although typically "silent," some pseudogenes are transcribed and may occasionally play roles in gene regulation, but they do not encode active proteins and thus are not conventional drug targets. The parent gene, FGFR3, encodes a receptor involved in cell proliferation, bone growth, and development, and is linked to diseases like achondroplasia. However, the pseudogene does not share those canonical functional roles. Pseudogenes can be processed (retrotransposed) or unprocessed (duplicated and mutated), but both lack the ability to make full, functional proteins. While rare cases exist of pseudogenes having regulatory RNA functions, these are the exception, not the rule, and require direct experimental evidence, which is not reported for this entry. This is not a therapeutic target, and is not used for direct drug discovery or patient biomarker guidance. Any indications of "FGFR3" as a therapeutic target refer to the functional protein, not its pseudogenes. In summary, ENSG00000237026 is a pseudogene related to FGFR3, not a functional receptor or drug target. For structured information or drug targeting, use the canonical FGFR3 protein-coding gene, not its pseudogenes.

Other names

FGFR3PFGFR3 PseudogeneFibroblast growth factor receptor 3 pseudogeneFGFR3P3

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