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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor 3c (FGFR3c)
- Target
- FGFR3c
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, Transmembrane protein
01
Overview
Fibroblast growth factor receptor 3c (FGFR3c) is an isoform of the FGFR3 protein, a receptor tyrosine kinase that regulates cell proliferation, differentiation, and development. It is predominantly expressed in mesenchymal tissues and has distinct FGF ligand affinities. Mutations or overexpression of FGFR3, including FGFR3c, are implicated in skeletal disorders and cancer, making it a therapeutic target. Upon activation, FGFR3c triggers intracellular signaling cascades like Ras/MAPK/ERK, PI(3)K/Akt, and PLCγ/PKC pathways.
- Other names
- CD333FGFR3
02
Mechanism of action
Upon ligand binding, FGFR3c dimerizes, activates its tyrosine kinase activity, and phosphorylates downstream targets, activating the Ras/MAPK/ERK, PI(3)K/Akt, and PLCγ/PKC pathways, influencing gene expression related to growth and development.
03
Biological functions
Cell proliferationDifferentiationAngiogenesisSignal transductionRegulation of ossificationChondrocyte proliferation control
04
Disease associations
AchondroplasiaHypochondroplasiaBladder cancerSeborrheic keratosesSkeletal disordersCancer
05
Safety considerations
Potential side effects from FGFR3 inhibitorsTherapeutic challenges in targeting specific FGFR3 mutations
06
Interacting drugs
Small molecule inhibitors targeting FGFR3
1 more in the full profile.
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